Blar i forfatter "Flatberg, Arnar"

Viser treff 1-4 av 4

    • Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study 

      Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar; Beisvag, Vidar; Nøst, Therese Haugdahl; Guida, Florence; Jiang, Lin; Wahl, Sissel Gyrid Freim; Langhammer, Arnulf; Skorpen, Frank; Walker, Rosie M; Bretherick, Andrew D; Zeng, Yanni; Chen, Yue; Johansson, Mattias; Sandanger, Torkjel M; Relton, Caroline L; Mai, Xiao-Mei (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-17)
      <i>Background</i> - It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated measurements, and to appraise the putative role of DNA methylation in the pathway between smoking and lung cancer development.<br><br> <i>Methods</i> - We derived a nested ...

    • Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma 

      Røe, Oluf Dimitri; Szulkin, Adam; Anderssen, Endre; Flatberg, Arnar; Sandeck, Helmut; Amundsen, Tore; Erlandsen, Sten Even; Dobra, Katalin; Sundstrøm, Stein Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Pemetrexed, a multi-folate inhibitor combined with a platinum compound is the first-line treatment of malignant mesothelioma, but median survival is still one year. Intrinsic and acquired resistance to pemetrexed is common, but its biological basis is obscure. Here we report for the first time a genome-wide profile of acquired resistance in the tumour from an exceptional case with advanced pleural ...

    • Patient derived colonoids as drug testing platforms - Critical importance of oxygen concentration 

      Skovdahl, Helene Kolstad; Gopalakrishnan, Shreya; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Bakke, Ingunn; Ginbot, Zekarias; Thorsvik, Silje; Flatberg, Arnar; Sporsheim, Bjørnar; Ostrop, Jenny; Mollnes, Tom Eirik; Sandvik, Arne Kristian; Bruland, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-13)
      Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there is an unmet need for biomarkers and assays to predict drug effect. It is well known that the intestinal epithelium is an important factor in disease pathogenesis, exhibiting physical, ...

    • Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study 

      Dumeaux, Vanessa; Ursini‐Siegel, Josie; Flatberg, Arnar; Fjøsne, Hans Erikssønn; Frantzen, Jan Ole; Holmen, Marit Muri; Rodegerdts, Enno; Schlichting, Ellen; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-14)
      Tumor–host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of malignant cells to hijack and exploit the normal physiological processes of the host. Here, we established that many genes within peripheral blood cells show differential expression when an untreated breast cancer (BC) is present, and harnessed this fact to construct a 50-gene ...